Evaluation of acute locoregional toxicity in patients with breast cancer treated with adjuvant radiotherapy in combination with bevacizumab.
Identifieur interne : 004F07 ( Main/Exploration ); précédent : 004F06; suivant : 004F08Evaluation of acute locoregional toxicity in patients with breast cancer treated with adjuvant radiotherapy in combination with bevacizumab.
Auteurs : Sharad Goyal [États-Unis] ; Malay S. Rao ; Atif Khan ; Lien Huzzy ; Camille Green ; Bruce G. HafftySource :
- International journal of radiation oncology, biology, physics [ 1879-355X ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (effets indésirables), Anticorps monoclonaux humanisés, Bévacizumab, Dosimétrie en radiothérapie, Fatigue (étiologie), Femelle, Humains, Inhibiteurs de l'angiogenèse (administration et posologie), Inhibiteurs de l'angiogenèse (effets indésirables), Lymphoedème (étiologie), Pneumopathie infectieuse (étiologie), Pneumopathie radique (étiologie), Radiosensibilisants (administration et posologie), Radiosensibilisants (effets indésirables), Radiothérapie adjuvante (effets indésirables), Sujet âgé, Trastuzumab, Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs du sein (traitement médicamenteux), Études cas-témoins.
- MESH :
- administration et posologie : Anticorps monoclonaux, Inhibiteurs de l'angiogenèse, Radiosensibilisants.
- anatomopathologie : Tumeurs du sein.
- effets indésirables : Anticorps monoclonaux, Inhibiteurs de l'angiogenèse, Radiosensibilisants, Radiothérapie adjuvante.
- radiothérapie : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- étiologie : Fatigue, Lymphoedème, Pneumopathie infectieuse, Pneumopathie radique.
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux humanisés, Bévacizumab, Dosimétrie en radiothérapie, Femelle, Humains, Sujet âgé, Trastuzumab, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Aged, Angiogenesis Inhibitors (administration & dosage), Angiogenesis Inhibitors (adverse effects), Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (adverse effects), Antibodies, Monoclonal, Humanized, Bevacizumab, Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Case-Control Studies, Fatigue (etiology), Female, Humans, Lymphedema (etiology), Middle Aged, Pneumonia (etiology), Radiation Pneumonitis (etiology), Radiation-Sensitizing Agents (administration & dosage), Radiation-Sensitizing Agents (adverse effects), Radiotherapy Dosage, Radiotherapy, Adjuvant (adverse effects), Trastuzumab.
- MESH :
- chemical , administration & dosage : Angiogenesis Inhibitors, Antibodies, Monoclonal, Radiation-Sensitizing Agents.
- chemical , adverse effects : Angiogenesis Inhibitors, Antibodies, Monoclonal, Radiation-Sensitizing Agents.
- adverse effects : Radiotherapy, Adjuvant.
- drug therapy : Breast Neoplasms.
- etiology : Fatigue, Lymphedema, Pneumonia, Radiation Pneumonitis.
- pathology : Breast Neoplasms.
- radiotherapy : Breast Neoplasms.
- Adult, Aged, Antibodies, Monoclonal, Humanized, Bevacizumab, Case-Control Studies, Female, Humans, Middle Aged, Radiotherapy Dosage, Trastuzumab.
Abstract
Preclinical studies have shown that bevacizumab combined with radiotherapy (RT) induces a radiosensitizing effect. Published reports regarding the safety of combination therapy involving bevacizumab and RT are lacking. The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent bevacizumab plus RT.
DOI: 10.1016/j.ijrobp.2009.11.021
PubMed: 20452134
Affiliations:
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Le document en format XML
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<term>Aged</term>
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<term>Angiogenesis Inhibitors (adverse effects)</term>
<term>Antibodies, Monoclonal (administration & dosage)</term>
<term>Antibodies, Monoclonal (adverse effects)</term>
<term>Antibodies, Monoclonal, Humanized</term>
<term>Bevacizumab</term>
<term>Breast Neoplasms (drug therapy)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Case-Control Studies</term>
<term>Fatigue (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphedema (etiology)</term>
<term>Middle Aged</term>
<term>Pneumonia (etiology)</term>
<term>Radiation Pneumonitis (etiology)</term>
<term>Radiation-Sensitizing Agents (administration & dosage)</term>
<term>Radiation-Sensitizing Agents (adverse effects)</term>
<term>Radiotherapy Dosage</term>
<term>Radiotherapy, Adjuvant (adverse effects)</term>
<term>Trastuzumab</term>
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<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Anticorps monoclonaux (effets indésirables)</term>
<term>Anticorps monoclonaux humanisés</term>
<term>Bévacizumab</term>
<term>Dosimétrie en radiothérapie</term>
<term>Fatigue (étiologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inhibiteurs de l'angiogenèse (administration et posologie)</term>
<term>Inhibiteurs de l'angiogenèse (effets indésirables)</term>
<term>Lymphoedème (étiologie)</term>
<term>Pneumopathie infectieuse (étiologie)</term>
<term>Pneumopathie radique (étiologie)</term>
<term>Radiosensibilisants (administration et posologie)</term>
<term>Radiosensibilisants (effets indésirables)</term>
<term>Radiothérapie adjuvante (effets indésirables)</term>
<term>Sujet âgé</term>
<term>Trastuzumab</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs du sein (traitement médicamenteux)</term>
<term>Études cas-témoins</term>
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<term>Antibodies, Monoclonal</term>
<term>Radiation-Sensitizing Agents</term>
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<term>Antibodies, Monoclonal</term>
<term>Radiation-Sensitizing Agents</term>
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<term>Inhibiteurs de l'angiogenèse</term>
<term>Radiosensibilisants</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy, Adjuvant</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term>
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<term>Inhibiteurs de l'angiogenèse</term>
<term>Radiosensibilisants</term>
<term>Radiothérapie adjuvante</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term>
<term>Lymphedema</term>
<term>Pneumonia</term>
<term>Radiation Pneumonitis</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Fatigue</term>
<term>Lymphoedème</term>
<term>Pneumopathie infectieuse</term>
<term>Pneumopathie radique</term>
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<term>Aged</term>
<term>Antibodies, Monoclonal, Humanized</term>
<term>Bevacizumab</term>
<term>Case-Control Studies</term>
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<term>Humans</term>
<term>Middle Aged</term>
<term>Radiotherapy Dosage</term>
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<term>Bévacizumab</term>
<term>Dosimétrie en radiothérapie</term>
<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Preclinical studies have shown that bevacizumab combined with radiotherapy (RT) induces a radiosensitizing effect. Published reports regarding the safety of combination therapy involving bevacizumab and RT are lacking. The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent bevacizumab plus RT.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>New Jersey</li>
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<tree><noCountry><name sortKey="Green, Camille" sort="Green, Camille" uniqKey="Green C" first="Camille" last="Green">Camille Green</name>
<name sortKey="Haffty, Bruce G" sort="Haffty, Bruce G" uniqKey="Haffty B" first="Bruce G" last="Haffty">Bruce G. Haffty</name>
<name sortKey="Huzzy, Lien" sort="Huzzy, Lien" uniqKey="Huzzy L" first="Lien" last="Huzzy">Lien Huzzy</name>
<name sortKey="Khan, Atif" sort="Khan, Atif" uniqKey="Khan A" first="Atif" last="Khan">Atif Khan</name>
<name sortKey="Rao, Malay S" sort="Rao, Malay S" uniqKey="Rao M" first="Malay S" last="Rao">Malay S. Rao</name>
</noCountry>
<country name="États-Unis"><region name="New Jersey"><name sortKey="Goyal, Sharad" sort="Goyal, Sharad" uniqKey="Goyal S" first="Sharad" last="Goyal">Sharad Goyal</name>
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